601 et seq.) The aPAD and cPAD represent the highest safe exposures, taking into account all appropriate SFs. Permethrin is a common and widely used ingredient in insecticides and insect repellents. These markup elements allow the user to see how the document follows the This repetition of headings to form internal navigation links Using the exposure assumptions described in this unit for chronic exposure, EPA has concluded that chronic exposure to uniconazole from food and water will utilize <1% of the cPAD for the general population and all population subgroups, including infants and children. As to residue levels in food, EPA again assumed that all foods covered by the fruiting vegetable tolerance contain tolerance-level residues and that 100% of fruiting vegetables are treated with uniconazole. Uniconazole (commercial names: Concise and Sumagic). What pesticides can you recommend? Some induce developmental, reproductive and neurological effects in rodents. Country USA. evaluate the effects of uniconazole drenches on the growth and flowering of young potted macadamia trees. on FederalRegister.gov Brand name: OravigDrug class: azole antifungals. 3. More information and documentation can be found in our The petitioner proposed a tolerance for residues of uniconazole-P Aggregate Risk Assessment and Determination of Safety, D. Safety Factor for Infants and Children, E. Aggregate Risks and Determination of Safety, VI. Although observed less consistently, increases in the activity of some enzymes indicated altered liver function as a response to uniconazole exposure. Quality standards dictate that most container-grown greenhouse crops be compact, have short internodes, have a height consistent with the container they are grown in and have strong stems. documents in the last year, 84 Ecological toxicity is particularly harsh on aquatic organisms and amphibians. [Reserved], updated on 11:25 AM on Monday, June 12, 2023, updated on 8:45 AM on Monday, June 12, 2023. All documents in the docket are listed in the docket index available in regulations.gov. , A data sheet from the Compendium of Pesticide Common Names, InChI=1S/C15H18ClN3O/c1-15(2,3)14(20)13(19-10-17-9-18-19)8-11-4-6-12(16)7-5-11/h4-10,14,20H,1-3H3/b13-8+, The (+)-enantiomer of this substance has the ISO common name. These tools are designed to help you understand the official document The POD selected for deriving the chronic reference dose (cRfD) will adequately account for all chronic effects determined to result from exposure to uniconazole in chronic animal studies, including potential cancer effects. documents in the last year, 17 Although short or dwarf cultivars exist for many greenhouse crop species, chemicals that further reduce plant height and increase the compactness and strength of the plant are often required. This chemical is commonly used on perennials because it is highly effective on a very broad range of plant species. gives more details. Uniconazole is a plant growth regulator. The triazole plant growth retardants are the most persistent (long lasting) of the plant growth retardants and because these materials are active at very low rates, the potential for error and crop overdose is greater than with other plant growth retardants. In contrast, if gibberellin production in the plant is reduced, it will be shorter and stronger with thicker stems and smaller leaves. Select one or more newsletters to continue. [Reserved], (d) Indirect or inadvertant residues. Triazole pyruvic acid and triazole lactic acid were not included in the risk assessment due to their low occurrence in metabolism studies. documents in the last year, 952 For linear cancer risks, EPA calculates the probability of additional cancer cases given the estimated aggregate exposure. . There was no evidence of increased qualitative or quantitative susceptibility of rabbit fetuses following in utero exposure to uniconazole and no evidence of increased susceptibility of offspring in the 2-generation reproduction study in rats. Acute exposure. There was evidence of increased qualitatative susceptibility of fetuses in the rat developmental study. Open for Comment, Economic Sanctions & Foreign Assets Control, State Enforcement of Inland Navigation Rules, National Oceanic and Atmospheric Administration, Federal Motor Carrier Safety Administration, Moving Beyond COVID-19 Vaccination Requirements for Federal Workers, Imposing Sanctions on Certain Persons Destabilizing Sudan and Undermining the Goal of a Democratic Transition. Some of the following links exit EPA's site The risk assessment is a highly conservative, screening-level evaluation in terms of hazards associated with common metabolites (e.g., use of a maximum combination of uncertainty factors) and potential dietary and non-dietary exposures (i.e., high end estimates of both dietary and non-dietary exposures). Thus, the Agency has determined that Executive Order 13132, entitled Federalism (64 FR 43255, August 10, 1999) and Executive Order 13175, entitled Consultation and Coordination with Indian Tribal Governments (65 FR 67249, November 9, 2000) do not apply to this final rule. For more information on the general principles EPA uses in risk characterization and a complete description of the risk assessment process, see http://www.epa.gov/pesticides/factsheets/riskassess.htm. Uniconazole-P is the most biologically active isomer. EPA's assessment of exposures and risks associated with establishing this tolerance follows. The following list includes links related to the selected substance. Section 180.643 is added to read as follows: (a) General. 1. In this study, we determined whether the application of uniconazole alone or combined with ethephon could enhance the seed-filling rates in maize by regulating the endogenous hormone contents. Mutagenicity studies were generally negative except for the in vitro mammalian chromosome aberration test (CHO), which was positive with metabolic activation. Trade Name CONCISE Label Indication, CB RN 733303. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. :8xUOs9]iOqLv:JbBDW|0 N1Y7BhWfD*32;s-*'r] cn,/ !R&1D$/+\Vk!FxJXovIQLn\aDBftWSh)0t 3}r It is soluble in water allowing potential groundwater and runoff contamination. Dietary exposure from drinking water. IUPAC Name (E)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol. - Mechanism of Action & Protocol. Uniconazole has moderate acute oral toxicity and low acute dermal and inhalation toxicity. It shows a moderate level of toxicity to most aquatic species . Based upon review of the data supporting the petition, EPA has modified the tolerance expression to include uniconazole-P, its R-enantiomer and its Z-isomer. Whats the worry with this chemical and cannabis? Formulation. documents in the last year, by the National Oceanic and Atmospheric Administration For information regarding EPA's efforts to determine which chemicals have a common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see EPA's website at http://www.epa.gov/pesticides/cumulative. >Y/Io]%u)@xhW(q}k establishing the XML-based Federal Register as an ACFR-sanctioned
