Clin Infect Dis 2008 Sep 1;47(5):64250. Lee et al. Background Klebsiella pneumoniae (K. pneumoniae) is a common cause of health-care associated infections (HAIs) and has high levels of antibiotic resistance. Molecular characterization of extended-spectrum -lactamases among clinical isolates of Escherichia coli & Klebsiella pneumoniae: a multi-centric study from tertiary care hospitals in India. 1. To date, 33 people have been confirmed to be infected with the strain of bacteria. Federal government websites often end in .gov or .mil. "While the risk of transmission is extremely low for patients, we continue to take proactive steps to avoid additional transmission, including conducting environmental sampling, updating facility infrastructure, and reviewing cleaning and infection prevention practices," the release states. Clinical and economic impact of common multidrug-resistant gram-negative bacilli. The higher rates of colonization are primarily related to the increasing use of antibiotics [3, 17, 18]. Emergence of OXA-48-producing Klebsiella pneumoniae in Taiwan. PLoS ONE. Radiol Case Rep. 2016 Sep 17;11(4):370-374. doi: 10.1016/j.radcr.2016.08.001. Siu LK, Yeh KM, Lin JC, Fung CP, Chang FY. Liu YC, Cheng DL, Lin CL. Microbiol Mol Biol Rev. Prompt identification and treatment are necessary to reduce patient morbidity and prevent mortality. 2015;10(9):e0139152. K. pneumoniae is facultatively anaerobic, oxidase-negative, and produces acid and gas from lactose. Doribax [prescribing information]. 2004 Nov;2(11):10328. Podschun R, Ullmann U. Klebsiella spp. According to Fang et al. Virulence and genomic feature of a virulent klebsiella pneumoniae sequence type 14 strain of serotype K2 harboring blaNDM5 in China. Characterize carbapenem-resistant Klebsiella pneumoniae isolates for nosocomial pneumonia and their Gram-negative bacteria neighbors in the respiratory tract. Andrade LN, Vitali L, Gaspar GG, Bellissimo-Rodrigues F, Martinez R, Darini AL. Klebsiella pneumoniae can cause different types of health care-associated infections, including pneumonia, bloodstream infections, wound or surgical site infections, and meningitis, the CDC states. We report a case of pan-susceptible HvKP infection in Navon-Venezia S, Kondratyeva K, Carattoli A. Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance. Klebsiella pneumoniae (K pneumoniae) is a gram-negative, gas-producing, capsulated, nonmotile, enteric bacillus.It exists widely in nature and is one of the normal flora in the human intestine and oral cavity. People with a compromised immune system and/or people who have an implanted medical device (such as a urinary catheter or airway tube) are more at risk for Klebsiella infections. 2019;8(1):46. 2015;112(27):E357481. Alizade H, Jajarmi M, Aflatoonian MR, Kalantar-Neyestanaki D, Shoja S, Ghanbarpour R. Comparative prevalence of blaCTX-m-15 gene with virulence genes and serotypes in Klebsiella pneumoniae. Klebsiella pneumoniae can infect a variety of sites, with the risk of infection being higher in the immunocompromised state such as diabetes mellitus. Google Scholar. 2012;45(2):1139. 2016;8(1):55. Provided by the Springer Nature SharedIt content-sharing initiative. J Clin Epidemiol. Community-acquired bacterial meningitis. 2018;4:2. Virginia Mason Medical Center said in the statement it is "difficult to determine whether Klebsiella pneumoniae caused or contributed" to the deaths since some patients' conditions were complex. There is a wide range of pathogens associated with pyogenic liver abscesses, which can be attributed to various factors such as medical interventions and immunosuppression statuses, as well as regional differences. [2], this organism accounts for about one-third of all Gram-negative infections such as urinary tract infections, cystitis, pneumonia, surgical wound infections, endocarditis and septicemia. K. pneumoniae is an extremely rare cause of bacterial meningitis. Here, the authors show that Spread of these extended-spectrum -lactamase (ESBL) and Carbapenemase-encoding plasmids poses a major threat, as acquisition of these plasmids turn bacteria into MDR and XDR. sharing sensitive information, make sure youre on a federal Front Cell Infect Microbiol. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Fimbria, according to Huang et al. Nucleic acid amplification testing for herpes simplex virus type 1 and type 2 DNA was negative, and Gram staining revealed no organisms. Privacy Lemierre's Syndrome Caused by Klebsiella pneumoniae in a Diabetic Patient: A Case Report and Review of the Literature. Find resources for patients and caregivers that address the challenges of living with a rare disease, Learn more about the different types of clinical studies, ResearchMatch helps connect people interested in research studies, UMLSVocabulary Standards and Mappings Downloads, Access aggregated data from Orphanet at Orphadata, National Center for Biotechnology Information's, Newborn Screening Coding and Terminology Guide, Improving newborn screening laboratory test ordering and result reporting using health information exchange, Health Literacy Online: A Guide for Simplifying the User Experience, U.S. Department of Health & Human Services, National Center for Advancing Translation Sciences, Ways to connect to others and share personal stories, Up-to-date treatment and research information, Lists of specialistsor specialty centers. Modern antibiotics are highly active in the treatment of wound infections. 2017;12(7):515. From Fig.1, it can be seen that there is an increasing trend in the isolation rate of K. pneumoniae (from 9.8% in 2005 to 13.3% in 2012) in China. We report a rare case of an invasive liver abscess caused by K. pneumoniae, with metastatic infections of meninges. wound infections. Hypermucoviscous K. pneumoniae (HMKP) strain types which are sporadically distributed in Asia and the Middle East are the NDM-producing isolates [12, 13]. Klebsiella pneumoniae is an opportunistic pathogen and leading cause of hospital-associated infections. From Table2, it can be seen that K. pneumoniae has a great resistance rate to most of the commonly used antimicrobials. To find the right clinical study we recommend you: ResearchMatch helps connect people interested in research studieswith researchers from top medical centers across the United States. In Asia, it has been reported that exposure to health care facility and history of previous overseas hospitalization (OR: 33.667; 95% CI 4.539259.700) is one of the notifiable risk factors associated with K. pneumoniae colonization but this had been disagreed by Ling et al. A 68-year-old man with type 2 diabetes mellitus and deep vein thrombosis, who had refused medical treatment for personal reasons for one year, presented at the emergency department after two weeks of general weakness. PubMed Central We report a 58-year-old woman with a past medical history of uncontrolled diabetes who presented with Diabetes mellitus or impaired fasting glucose is the major observed risk factor for K. pneumoniae primary liver abscess; these conditions are not major risk factors for liver abscesses caused by organisms other than Klebsiella [1, 20]. WebKlebsiella pneumoniae is a Gram-negative, non-motile, encapsulated, lactose - fermenting, facultative anaerobic, rod-shaped bacterium. A common destructive complication is pyogenic liver abscess that can be complicated by metastatic endophthalmitis as well as the involvement of the central nervous system, causing purulent meningitis or brain abscess. It can be concluded that antimicrobial resistance in K. pneumoniae is a clear and present danger in Asia which needs strong surveillance to curb this menace. Infectious Diseases Society of America. 1998 Aug;17(8):55660. J Microbiol Immunol Infect. These usually develop in hospital settings. But if K. pneumoniae gets into other areas of The rmpA and rmpA2 are Plasmid-carried genes, which contribute to the enhancement of capsular production. Klebsiella [klebseeelluh] is a type of gram-negative bacteria that can cause different types of healthcare-associated infections, including pneumonia, J Formos Med Assoc. 2002;26(5):3405. Resource(s) for Medical Professionals and Scientists on This Disease: This information is currently in development. Tian D, Pan F, Wang C, Sun Y, Zhang H. Resistance phenotype and clinical molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae among pediatric patients in Shanghai. By using this website, you agree to our They often live in your intestines without giving you any problem. These bacteria are well-known for their ability to produce biofilm. Trends of resistance and isolation rate of K. pneumoniae in China. N Engl J Med. Klebsiella species include Klebsiella ozaenae, Klebsiella rhinoscleroma, and K. pneumoniae, the last of which is an important opportunistic and iatrogenic infectious pathogen with major clinical implications ( Bagley, 1985 ). 2000;30(1):5560. These numbers in terms of percentage resistance to the various antimicrobials ranges from no isolate (0%) to all isolates (100%). Clin Infect Dis. Escherichia coli and K. pneumoniae are frequently identified as pathogens [5], but a series of cases in the United States showed that the Streptococcus milleri group was the most commonly found pathogen [6, 7]. If material is not included in the articles Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. A rarer condition is K. pneumoniae meningitis presenting as acute hemiplegia. Thornton A, Lee P. Publication bias in meta-analysis: its causes and consequences. Tsai FC, Huang YT, Chang LY, Wang JT. Klebsiella pneumoniae: the classical and other subtypes. volume23, Articlenumber:397 (2023) 2015;1(37):10712. 2007 Aug 1;45(3):284 93. There are a number of virulence factors that We report a rare case of an invasive liver abscess caused by K. pneumoniae, with metastatic infections of meninges, presenting with acute hemiplegia and gaze preference mimicking a cerebrovascular accident. J Clin Microbiol. Pyogenic liver abscess as endemic disease, Taiwan. 2022 Jan;114:18591. Klebsiella pneumoniae is a contagious bacteria that can cause infections such as pneumonia and sepsis. Jpn J Infect Dis. In this review, although there is an increasing trend in the isolation rate, their resistance rates were not in tandem as this was evident in the decreasing trends over the years. In humans, Klebsiella often colonizes the nasal and digestive tract without causing any symptomatic disease. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. 2002;8:16066. PubMed Pollack M, Nieman R, Reinhardt J, Charache P, Jett M, Hardy JRP. Effah, C.Y., Sun, T., Liu, S. et al. A lobulated hypodense and hypoenhancing hepatic mass (arrow) with internal necrotic areas located at S8 causing thrombosis of an intrahepatic portal vein. All authors participated in writing and revising the manuscript. Transthoracic echocardiogram revealed normal contractility without vegetation. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Klebsiella pneumoniae can be broadly classified into two subtypes; classical Klebsiella pneumoniae (cKp) and non-classical Klebsiella pneumoniae (ncKp). Springer Nature. The site is secure. Lee SS, Chen YS, Tsai HC, Wann SR, Lin HH, Huang CK, Liu YC. Antimicrob Agents Chemother. Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Klebsiella pneumoniae can infect a variety of sites, with the risk of infection being higher in the immunocompromised state such as diabetes mellitus. Researchers from participating institutions use the database to search for and invite patients or healthy volunteers who meet their study criteria to participate. Careers. Lancet. In Fig.1, there is a steady increase in resistance of imipenem over the years and this can be as a result of their increasing use among the populace. Erratum in: N Engl J Med. Asian Pac J Trop Med. 2016;80(3):62961. J Infect Dis. Therefore, the aim of this study was to determine the phenotypic and molecular characteristics of ESBL-producing E. coli and K. pneumoniae among The authors declare that they have no competing interests. Blood osmolality was 288 mOsm/kg. The Klebsiella pneumoniae bacteria infections were first detected at the Virginia Mason Medical Center campus in downtown Seattle in October 2022.. To date, Hypermucoviscous Klebsiella pneumoniae (HvKP) is a hypervirulent strain of Klebsiella that causes metastatic spread and life-threatening infection. We report a 58-year-old woman with a past medical history of uncontrolled diabetes who presented with abdominal pain along with swelling in the left third finger and left calf. 2014;82(6):235667. Klebsiella species include Klebsiella ozaenae, Klebsiella rhinoscleroma, and K. pneumoniae, the last of which is an important opportunistic and iatrogenic Risk factors for acquisition of carbapenem resistant Enterobacteriaceae in an acute tertiary care hospital in Singapore. Purpose To demonstrate the feasibility of continuous infusion of meropenemvaborbactam to optimize the treatment of carbapenem-resistant Meningococcal disease. Diagn Microbiol Infect Dis. WebUrinary tract infection and pneumonia are common diseases caused by Klebsiella pneumoniae.In rare circumstances, Klebsiella pneumoniae has been associated with Delays in diagnosis and treatment can increase morbidity and mortality, with mortality rates reaching 70% without treatment [32]. Google Scholar. In K. pneumoniae, the blaKPC genes which confers reduced susceptibility or resistance to nearly all -lactam antibiotics by various enterobacteria are mostly carried on plasmids. Shankar C, Nabarro LE, Ragupathi NK, Sethuvel DP, Daniel JL, Veeraraghavan B. WebUrinary tract infection and pneumonia are common diseases caused by Klebsiella pneumoniae.In rare circumstances, Klebsiella pneumoniae has been associated with abscess formation, thrombosis, septic emboli, and infective endocarditis. An official website of the United States government. The most common condition caused by Klebsiella bacteria outside the hospital is pneumonia, typically in the form of bronchopneumonia and also bronchitis. Raritan, NJ: Janssen Pharmaceuticals, Inc. ; 2014. Bethesda, MD 20894, Web Policies 2008 May;30(5):86883. Infection and drug resistance. In fact, Klebsiellae account for up to 8% of all hospital-acquired infections. Clin Infect Dis. 2002 Dec;95(12):797802. Yu WL, Ko WC, Cheng KC, Lee CC, Lai CC, Chuang YC. Meddings L, Myers RP, Hubbard J, Shaheen AA, Laupland KB, Dixon E, Coffin C, Kaplan GG. Colonization, infection, and the Accessory Genome of Klebsiella pneumoniae. The .gov means its official. He was successfully extubated and transferred to a general ward on the 10th day. statement and Terrin N, Schmid CH, Lau J. In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias. Rosenstein NE, Perkins BA, Stephens DS, Popovic T. Hughes. The increase in colonization rate of K. pneumoniae as observed in these clinical samples is of epidemiological important because, Klebsiella nosocomial infection was four times higher in stool carriers compared with non-carriers [19]. In this study was aimed to determine resistance of K. pneumoniae screened FEMS Microbiol Rev. After the patient received medical care for about six hours at our emergency department, sudden disturbed consciousness was noticed by the family with presentation of conjugate eye deviation to the left and severe left-sided hemiparesis (muscle strength grading of 1/5). Vikas Gautam, Thaku Anjana, Sharm Megha, Singh Avinash, Bansal Shruti, Sharma Aditi. Because of the limited number of studies included in this meta-analysis, this study did not assess for publication bias because according to Terrin and Schmid [37] and Thornton and Lee [38], funnel plots and statistical tests for detection of publication bias are unreliable for limited number of studies. On the sixth hospital day, he fully recovered consciousness. Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes. 1). Semin Perinatol. Web1 Introduction. This review was therefore designed to determine the antibiotic-resistant profiles of Klebsiella pneumonia as a nosocomial pathogen and focuses on some differences between classical and non-classical subtypes, antimicrobial resistance-mediated genes, some virulent factors of this organism, and some epidemiological risk factors through a systematic review and meta-analysis. Lee CR, Lee JH, Park KS, Jeon JH, Kim YB, Cha CJ, Jeong BC, Lee SH. Infect Immun. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. But klebsiella pneumoniae can be dangerous if they get PubMedGoogle Scholar. 2005 Mar 3;352(9):950. Klebsiella pneumoniae liver abscess associated with septic endophthalmitis. 2005;58(9):894901. No focal neurological deficit was observed. Trends in antibiotic susceptibility and incidence of late-onset Klebsiella pneumoniae neonatal sepsis over a 6-year period in a neonatal intensive care unit in Karachi, Pakistan. Rollin G, Rossi B, Brisse S, Decr D, Leflon-Guibout V, Bert F, Hoffmann I, Decousser JW, Fantin B, Lefort A. Spontaneous and postsurgical/traumatic Klebsiella pneumoniae meningitis: two distinct clinico-microbiological entities. [21], it was reported that some risk factors associated with K. pneumoniae sepsis and mortality in a neonate intensive care units in Pakistan were; extremely low birth weight (p=0.01, OR 6.1, 95% CI 0.844.4), being a male (p=0.06, OR 9.2, 95% CI 1.366.9), severe thrombocytopenia (p=0.07, OR 3.9, 95% CI 1.213.0), and failure to achieve microbiological clearance (p<0.001, OR 19.6, 95% CI 4.098.0).
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